Glycodendrimers as Chondroitin Sulfate Mimetics: Synthesis and Binding to Growth Factor Midkine
نویسندگان
چکیده
منابع مشابه
End-functionalized glycopolymers as mimetics of chondroitin sulfate proteoglycans.
Glycosaminoglycans are sulfated polysaccharides that play important roles in fundamental biological processes, such as cell division, viral invasion, cancer and neuroregeneration. The multivalent presentation of multiple glycosaminoglycan chains on proteoglycan scaffolds may profoundly influence their interactions with proteins and subsequent biological activity. However, the importance of this...
متن کاملChondroitin Sulfate Tetrasaccharides: Synthesis, Three-Dimensional Structure and Interaction with Midkine.
The biological activity of midkine, a cytokine implicated in neuro- and tumourigenesis, is regulated by its binding to glycosaminoglycans (GAGs), such as heparin and chondroitin sulfate (CS). To better understand the molecular recognition of GAG sequences by this growth factor, the interactions between synthetic chondroitin sulfate-like tetrasaccharides and midkine were studied by using differe...
متن کاملIntracellular Synthesis of Chondroitin Sulfate
In autoradiograms of slices of costal cartilage, incubated for 4 hours in a salt solution containing S(35)-sulfate and then washed extensively and dehydrated, about 85 per cent of the radioactivity was assignable to the chondrocytes. From alkaline extracts of similarly prepared slices of cartilage, 64 to 83 per cent of the total sulfur-35 in the slices was isolated as chondroitin sulfate by chr...
متن کاملSolution structure of midkine, a new heparin-binding growth factor.
Midkine (MK) is a 13 kDa heparin-binding polypeptide which enhances neurite outgrowth, neuronal cell survival and plasminogen activator activity. MK is structurally divided into two domains, and most of the biological activities are located on the C-terminal domain. The solution structures of the two domains were determined by NMR. Both domains consist of three antiparallel beta-strands, but th...
متن کاملThe binding of cations by chondroitin sulfate.
The polyelectrolyte nature of chondroitin sulfate and related polysaccharides suggests they may bind cations. Since chondroitin sulfate is an extracellular component of mammalian connective tissue, the binding properties of this polyelectrolyte for cations may be of significance in the distribution and storage of extracellular cations. In disease states in which sodium is known to play a major ...
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ژورنال
عنوان ژورنال: Chemistry - A European Journal
سال: 2017
ISSN: 0947-6539
DOI: 10.1002/chem.201701890